Abstract
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-β, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-β–driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-β in fibrosis, highlighting mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation.
Keywords
Transforming growth factorFibrosisGrowth factorMedicinePathologyInternal medicine
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Publication Info
- Year
- 2020
- Type
- review
- Volume
- 217
- Issue
- 3
- Pages
- e20190103-e20190103
- Citations
- 1093
- Access
- Closed
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Cite This
Nikolaos G. Frangogiannis
(2020).
Transforming growth factor–β in tissue fibrosis.
The Journal of Experimental Medicine
, 217
(3)
, e20190103-e20190103.
https://doi.org/10.1084/jem.20190103
Identifiers
- DOI
- 10.1084/jem.20190103