The Sequence of the Human Genome
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp ...
Publications
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753 publications
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, ...
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States
The prevalence of psychiatric disorders is greater than previously thought to be the case. Furthermore, this morbidity is more highly concentrated than previously recognized in ...
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior od...
Structure, function and diversity of the healthy human microbiome
Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this...
Fit indices in covariance structure modeling: Sensitivity to underparameterized model misspecification.
This study evaluated the sensitivity of maximum likelihood (ML)-, generalized least squares (GLS)-, and asymptotic distribution-free (ADF)-based fit indices to model misspecific...