Publications

Development of the Human Infant Intestinal Microbiota

Almost immediately after a human being is born, so too is a new microbial ecosystem, one that resides in that person's gastrointestinal tract. Although it is a universal and int...

Analog VLSI and Neural Systems

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Ageing and age-related diseases share some basic mechanistic pillars that largely converge on inflammation. During ageing, chronic, sterile, low-grade inflammation - called infl...

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Inflammatory bowel diseases, which include Crohn’s disease and ulcerative colitis, affect several million individuals worldwide. Crohn’s disease and ulcerative colitis are compl...

Environment dominates over host genetics in shaping human gut microbiota

Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from ...

The role of short-chain fatty acids in microbiota–gut–brain communication

Short-chain fatty acids (SCFAs), the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract, are speculated to have a key role in mic...

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic cons...

Improved Survival of Patients With Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial

For patients with HNSCC of the oropharynx, tumor HPV status is strongly associated with therapeutic response and survival.

The effects of bonus schemes on accounting decisions

Studies examining managerial accounting decisions postulate that executives rewarded by earnings-based bonuses select accounting procedures that increase their compensation. The...

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones....

Citation Analysis as a Tool in Journal Evaluation

As a communications system, the network of journals that play a paramount role in the exchange of scientific and technical information is little understood. Periodically since 1...

Covid-19 in Critically Ill Patients in the Seattle Region — Case Series

During the first 3 weeks of the Covid-19 outbreak in the Seattle area, the most common reasons for admission to the ICU were hypoxemic respiratory failure leading to mechanical ...