Publications

Proposals for the Classification of the Acute Leukaemias F<scp>rench</scp>‐A<scp>merican</scp>‐B<scp>ritish</scp> (FAB) C<scp>o‐operative</scp> G<scp>roup</scp>

S ummary . A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases en...

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse, which is associated with clonal evolution at the cytogenetic level. To determine the...

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and...

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Acute myeloid leukaemia is a highly malignant haematopoietic tumour that affects about 13,000 adults in the United States each year. The treatment of this disease has changed li...

Functional genomic landscape of acute myeloid leukaemia

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Non-coding recurrent mutations in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe...

Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia

Solution structure of the nonmethyl‐CpG‐binding CXXC domain of the leukaemia‐associated MLL histone methyltransferase

Methylation of CpG dinucleotides is the major epigenetic modification of mammalian genomes, critical for regulating chromatin structure and gene activity. The mixed-lineage leuk...

Stem cell origins of leukaemia and curability

It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell populations that are funct...