Bruce W. Birren

Transformation of<i>Escherichia coli</i>with large DNA molecules by electroporation

We have examined bacterial electroporation with a specific interest in the transformation of large DNA, i.e. molecules > 100 kb. We have used DNA from bacterial artificial chrom...

Initial sequencing and analysis of the human genome

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collabor...

Initial sequencing and comparative analysis of the mouse genome

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Independent Large Scale Duplications in Multiple M. tuberculosis Lineages Overlapping the Same Genomic Region

Mycobacterium tuberculosis, the causative agent of most human tuberculosis, infects one third of the world's population and kills an estimated 1.7 million people a year. With th...

Full-length transcriptome assembly from RNA-Seq data without a reference genome