Elizabeth H. Blackburn

Structure and function of telomeres

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

DNA sequences of telomeres maintained in yeast

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerou...

Generation of telomere-length heterogeneity in Saccharomyces cerevisiae.

Chromosome ends in the lower eukaryotes terminate in variable numbers of tandem, simple DNA repeats. We tested predictions of a model in which these telomeric repeats provide a ...

Dynamics of telomere length variation in tetrahymena thermophila

Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers.

A telomere terminal transferase activity was identified in developing macronuclear extracts from Euplotes crassus. The activity was essentially unregulated in vitro: up to 50 ta...