Carol W. Greider

Telomerase, Cell Immortality, and Cancer

An important hallmark of cancer is aberrant growth control. Genetic changes that confer a growth advantage to the tumor cell are observed on numerous levels. Some of the best un...

Identification of a nonprocessive telomerase activity from mouse cells.

Telomerase activity was identified in extracts from several different mouse cell lines. Addition of telomeric TTAGGG repeats was specific to telomeric oligonucleotide primers an...

Telomeres shorten during ageing of human fibroblasts

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

Telomere length predicts replicative capacity of human fibroblasts.

When human fibroblasts from different donors are grown in vitro, only a small fraction of the variation in their finite replicative capacity is explained by the chronological ag...

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis