Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SM...
An adaption of Egger regression (which we call MR-Egger) can detect some violations of the standard instrumental variable assumptions, and provide an effect estimate which is no...
Abstract Asymmetry in the funnel plot for a meta‐analysis suggests the presence of dissemination bias. This may be caused by publication bias through the decisions of journal ed...
ABSTRACT Developments in genome‐wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization rel...
Abstract In many ways, adjustment for publication bias in meta‐analysis parallels adjustment for ascertainment bias in genetic studies. We investigate a previously published sim...
The MBE relaxes the instrumental variable assumptions, and should be used in combination with other approaches in sensitivity analyses.
Mendelian randomization investigations are becoming more powerful and simpler to perform, due to the increasing size and coverage of genome-wide association studies and the incr...
Mendelian randomization (MR) uses genetic data to probe questions of causality in epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent yea...
This study focused on resolving the relationship between BMI and type 2 diabetes. The availability of multiple variants associated with BMI offers a new chance to resolve the tr...
Thank you for the opportunity to respond to the thoughtful and timely letter by Hartwig and Davies.
Abstract Background Two-sample summary data Mendelian randomization (MR) incorporating multiple genetic variants within a meta-analysis framework is a popular technique for asse...
: Care must be taken to assess the NOME assumption via the IGX2 statistic before implementing standard MR-Egger regression in the two-sample summary data context. If IGX2 is suf...
Abstract Odds ratios or other effect sizes estimated from genome scans are upwardly biased, because only the top‐ranking associations are reported, and moreover only if they rea...
Abstract Background Summary data furnishing a two-sample Mendelian randomization study are often visualized with the aid of a scatter plot, in which single nucleotide polymorphi...
h-index: Number of publications with at least h citations each.