Jian Yang

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Defining the role of common variation in the genomic and biological architecture of adult human height

GCTA: A Tool for Genome-wide Complex Trait Analysis

Common SNPs explain a large proportion of the heritability for human height

Five Years of GWAS Discovery

The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs). These studies were aime...

Genomic inflation factors under polygenic inheritance

Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide association studies (GWAS). Usually, the scaled...

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

Abstract Both polygenicity 1,2 ( i.e. many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification 3 , can yield inflated distri...

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined a...