Peter M. Visscher

Calculating statistical power in Mendelian randomization studies

In Mendelian randomization (MR) studies, where genetic variants are used as proxy measures for an exposure trait of interest, obtaining adequate statistical power is frequently ...

GCTA: A Tool for Genome-wide Complex Trait Analysis

Finding the missing heritability of complex diseases

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Common SNPs explain a large proportion of the heritability for human height

Increased accuracy of artificial selection by using the realized relationship matrix

Summary Dense marker genotypes allow the construction of the realized relationship matrix between individuals, with elements the realized proportion of the genome that is identi...

Genetic pleiotropy in complex traits and diseases: implications for genomic medicine

Several recent papers have used summary results from genome-wide association studies to characterize genetic overlap between human complex traits and common diseases.The emergin...

Sizing up human height variation

Five Years of GWAS Discovery

The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs). These studies were aime...

Genomic inflation factors under polygenic inheritance

Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide association studies (GWAS). Usually, the scaled...