Estimation of allele frequency and association mapping using next-generation sequencing data

Abstract

Overall, our results suggest that association mapping and estimation of allele frequencies should not be based on genotype calling in low to medium coverage data. Furthermore, if genotype calling methods are used, it is usually better not to filter genotypes based on the call confidence score.

Keywords

Allele frequencyComputational biologyDNA sequencingDNA microarrayAlleleGeneticsBiologyGenetic associationComputer scienceGenotypeSingle-nucleotide polymorphismDNAGene

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Publication Info

Year: 2011
Type: article
Volume: 12
Issue: 1
Pages: 231-231
Citations: 247
Access: Closed

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APA Style

                            
                                
                                    Su Yeon Kim, 
                                
                                    Kirk E. Lohmueller, 
                                
                                    Anders Albrechtsen
                                
                                et al.
                            
                            (2011). 
                            Estimation of allele frequency and association mapping using next-generation sequencing data. 
                            BMC Bioinformatics
                            , 12
                            (1)
                            , 231-231.
                            https://doi.org/10.1186/1471-2105-12-231
                        

Identifiers

DOI: 10.1186/1471-2105-12-231