William R. Sellers

Next-generation characterization of the Cancer Cell Line Encyclopedia

<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGF...

The landscape of somatic copy-number alteration across human cancers

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to a...

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

BRAF mutation predicts sensitivity to MEK inhibition

High-throughput oncogene mutation profiling in human cancer

Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma

Abstract The classification of human tumors based on molecular criteria offers tremendous clinical potential; however, discerning critical and “druggable” effectors on a large s...

Advances in the preclinical testing of cancer therapeutic hypotheses

Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas

Abstract Purpose: A significant number of women with serous ovarian cancer are intrinsically refractory to platinum-based treatment. We analyzed somatic DNA copy number variatio...