Woodring E. Wright

Telomerase, Cell Immortality, and Cancer

An important hallmark of cancer is aberrant growth control. Genetic changes that confer a growth advantage to the tumor cell are observed on numerous levels. Some of the best un...

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was de...

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.

IMR-90 normal human diploid fibroblasts, transfected with a steroid inducible mouse mammary tumor virus-driven simian virus 40 T antigen, were carried through crisis to yield an...

Defining the molecular mechanisms of human cell immortalization

Reversible Cellular Senescence: Implications for Immortalization of Normal Human Diploid Fibroblasts

IMR-90 normal human diploid fibroblasts, transfected with a steroid inducible mouse mammary tumor virus-driven simian virus 40 T antigen, were carried through crisis to yield an...