Telomerase, Cell Immortality, and Cancer

Calvin B. Harley; Naomy Kim; Karen R. Prowse; Scott L. Weinrich; Ken S. Hirsch; Michael D. West; Silvia Bacchetti; Hal W. Hirte; Christopher M. Counter; Carol W. Greider; Mieczyslaw A. Piatyszek; Woodring E. Wright; Jerry W. Shay

doi:10.1101/sqb.1994.059.01.035

Abstract

An important hallmark of cancer is aberrant growth control. Genetic changes that confer a growth advantage to the tumor cell are observed on numerous levels. Some of the best understood are mutations in proto-oncogenes and tumor suppressor genes that are linked to signal transduction pathways, cell cycle control, or cell-cell/cell-matrix interactions that regulate growth, movement, differentiation, survival, apoptosis, and genetic stability (Hartwell 1992; Weinberg 1992; Hunter 1993; Runger et al. 1994; Workman 1994). However, in addition to aberrant growth control, many cancer cells possess another important feature which distinguishes them from normal somatic cells: unlimited replicative capacity.

Keywords

TelomeraseSomatic cellBiologyCell cycleCell growthCellCancer cellCancerSignal transductionCell biologyGeneticsSuppressorCell divisionCancer researchGene

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Publication Info

Year: 1994
Type: review
Volume: 59
Issue: 0
Pages: 307-315
Citations: 400
Access: Closed

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APA Style

                            
                                
                                    Calvin B. Harley, 
                                
                                    Naomy Kim, 
                                
                                    Karen R. Prowse
                                
                                et al.
                            
                            (1994). 
                            Telomerase, Cell Immortality, and Cancer. 
                            Cold Spring Harbor Symposia on Quantitative Biology
                            , 59
                            (0)
                            , 307-315.
                            https://doi.org/10.1101/sqb.1994.059.01.035
                        

Identifiers

DOI: 10.1101/sqb.1994.059.01.035