Enzo Life Sciences (United States)

A core gut microbiome in obese and lean twins

Genome sequencing in microfabricated high-density picolitre reactors

The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly...

The complete genome of an individual by massively parallel DNA sequencing

The association of genetic variation with disease and drug response, and improvements in nucleic acid technologies, have given great optimism for the impact of 'genomic medicine...

A universal SNP and small-indel variant caller using deep neural networks

Despite rapid advances in sequencing technologies, accurately calling genetic variants present in an individual genome from billions of short, errorful sequence reads remains ch...

Rare Variants of <i>IFIH1</i> , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

Genome-wide association studies (GWASs) are regularly used to map genomic regions contributing to common human diseases, but they often do not identify the precise causative gen...

Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins

We deeply sampled the organismal, genetic, and transcriptional diversity in fecal samples collected from a monozygotic (MZ) twin pair and compared the results to 1,095 communiti...

A massively parallel PicoTiterPlate™ based platform for discrete picoliter‐scale polymerase chain reactions

Abstract We demonstrate successful, simultaneous polymerase chain reaction (PCR) amplification of up to 300 000 discrete reactions in a novel platform, the PicoTiterPlate™. In a...