Michael R. Stratton

The repertoire of mutational signatures in human cancer

Signatures of mutational processes in human cancer

The cancer genome

International network of cancer genome projects

Mutational Processes Molding the Genomes of 21 Breast Cancers

The Life History of 21 Breast Cancers

Deciphering Signatures of Mutational Processes Operative in Human Cancer

A Hypermutation Phenotype and Somatic <i>MSH6</i> Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

Abstract Malignant gliomas have a very poor prognosis. The current standard of care for these cancers consists of extended adjuvant treatment with the alkylating agent temozolom...

Author response: DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Me...

The landscape of cancer genes and mutational processes in breast cancer

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncog...

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations

Our study has identified key features of the histologic phenotypes of breast cancers in carriers of mutant BRCA1 and BRCA2 genes. This information may improve the classification...

Mutations of the BRAF gene in human cancer

Bayesian refinement of association signals for 14 loci in 3 common diseases

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136,000 coding mutations i...