Abstract
The genomes of eukaryotic cells are under continuous assault by environmental agents (e.g., UV light and reactive chemicals) as well as the byproducts of normal intracellular metabolism (e.g., reactive oxygen intermediates and inaccurately replicated DNA).Whatever the origin, genetic damage threatens cell survival, and, in metazoans, leads to organ failure, immunodeficiency, cancer, and other pathologic sequelae.
Keywords
BiologyKinaseCell biologyCHEK1Protein-Serine-Threonine KinasesCell cycleSignal transductionCell Cycle ProteinG2-M DNA damage checkpointCell cycle checkpointCell cycle progressionCancer researchCellGeneticsProtein kinase A
Affiliated Institutions
Related Publications
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine
Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allow time for DNA repair. Chemical inhibitors of the G(2) phase DNA damage check...
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation
The checkpoint kinase ATM is centrally involved in the cellular response to DNA double-strand breaks. However, the mechanism of ATM activation during genotoxicstress is only par...
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellul...
Oncogenic kinase signalling
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and multicellular communication in metazoans. Their ...
Genomic instability and endoreduplication triggered by <i>RAD17</i> deletion
Cell cycle checkpoints are critical for genomic stability. Rad17, a component of the checkpoint clamp loader complex (Rad17/Rfc2-5), is required for the response to DNA damage a...
Publication Info
- Year
- 2001
- Type
- review
- Volume
- 15
- Issue
- 17
- Pages
- 2177-2196
- Citations
- 1953
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1953
OpenAlex
Cite This
Robert T. Abraham
(2001).
Cell cycle checkpoint signaling through the ATM and ATR kinases.
Genes & Development
, 15
(17)
, 2177-2196.
https://doi.org/10.1101/gad.914401
Identifiers
- DOI
- 10.1101/gad.914401