DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao; Xiaoguang Liu; Yilei Zhang; Guang Lei; Yuelong Yan; Hyemin Lee; Pranavi Koppula; Shiqi Wu; Li Zhuang; Bingliang Fang; Masha V. Poyurovsky; Kellen Olszewski; Boyi Gan

doi:10.1038/s41586-021-03539-7

Keywords

GPX4Dihydroorotate dehydrogenaseLipid peroxidationCancer cellMitochondrionProgrammed cell deathCell biologyCancer researchChemistryBiologyBiochemistryCancerApoptosisSuperoxide dismutaseOxidative stressEnzymeGlutathione peroxidase

MeSH Terms

AnimalsBiphenyl CompoundsCell LineTumorDihydroorotate DehydrogenaseFemaleFerroptosisGene DeletionHumansLipid PeroxidationMetabolomicsMiceNudeMitochondriaNeoplasmsPhospholipid Hydroperoxide Glutathione PeroxidaseXenograft Model Antitumor AssaysMice

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Publication Info

Year: 2021
Type: article
Volume: 593
Issue: 7860
Pages: 586-590
Citations: 1549
Access: Closed

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APA Style

                            
                                
                                    Chao Mao, 
                                
                                    Xiaoguang Liu, 
                                
                                    Yilei Zhang
                                
                                et al.
                            
                            (2021). 
                            DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. 
                            Nature
                            , 593
                            (7860)
                            , 586-590.
                            https://doi.org/10.1038/s41586-021-03539-7
                        

Identifiers

DOI: 10.1038/s41586-021-03539-7
PMID: 33981038
PMCID: PMC8895686

Data Quality

Data completeness: 72%