Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Abstract

Treatment with drotrecogin alfa activated significantly reduces mortality in patients with severe sepsis and may be associated with an increased risk of bleeding.

Keywords

Drotrecogin alfaMedicinePlaceboSepsisInternal medicineClinical endpointAdverse effectRandomized controlled trialSurgerySeptic shockSevere sepsisPathology

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Publication Info

Year: 2001
Type: article
Volume: 344
Issue: 10
Pages: 699-709
Citations: 6116
Access: Closed

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APA Style

                            
                                
                                    Gordon R. Bernard, 
                                
                                    Jean‐Louis Vincent, 
                                
                                    Pierre‐François Laterre
                                
                                et al.
                            
                            (2001). 
                            Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis. 
                            New England Journal of Medicine
                            , 344
                            (10)
                            , 699-709.
                            https://doi.org/10.1056/nejm200103083441001
                        

Identifiers

DOI: 10.1056/nejm200103083441001