Jean‐Louis Vincent

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Treatment with drotrecogin alfa activated significantly reduces mortality in patients with severe sepsis and may be associated with an increased risk of bleeding.

Surviving Sepsis Campaign

To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. A consensus committee of 68 internat...

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

This document reflects a process whereby a group of experts and opinion leaders revisited the 1992 sepsis guidelines and found that apart from expanding the list of signs and sy...

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

OBJECTIVE: In 2003, critical care and infectious disease experts representing 11 international organizations developed management guidelines for severe sepsis and septic shock t...

The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects*

The administration of 5 mug/kg.min dobutamine can improve but not restore capillary perfusion in patients with septic shock. These changes are independent of changes in systemic...

Fluid challenge revisited

On completion of this article, the reader should be able to: 1. Explain the signs of hypovolemia. 2. Describe how to administer a fluid challenge. 3. Use this information in a c...

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis

A 72-hr, continuous intravenous infusion of rhIL-1ra failed to demonstrate a statistically significant reduction in mortality when compared with standard therapy in this multice...

From the bench to the bedside: the future of sepsis research. Executive summary of an American College of Chest Physicians, National Institute of Allergy and Infectious Disease, and National Heart, Lung, and Blood Institute Workshop.