Abstract

Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. Moreover, current research has exemplified just how complex this phenomenon is in cancer, leaving many exciting, open questions for researchers to answer in the future. With these points in mind, we asked four scientists for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.

Keywords

PhenomenonCancerEpithelial–mesenchymal transitionEmbryonic stem cellBiologyCancer researchEngineering ethicsMetastasisEpistemologyGeneticsEngineering

MeSH Terms

Epithelial-Mesenchymal TransitionHumansNeoplasms

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Publication Info

Year
2018
Type
review
Volume
18
Issue
2
Pages
128-134
Citations
1886
Access
Closed

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Cite This

Thomas Brabletz, Raghu Kalluri, M. Ángela Nieto et al. (2018). EMT in cancer. Nature reviews. Cancer , 18 (2) , 128-134. https://doi.org/10.1038/nrc.2017.118

Identifiers

DOI
10.1038/nrc.2017.118
PMID
29326430

Data Quality

Data completeness: 81%