Robert A. Weinberg

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

Understanding the tumor immune microenvironment (TIME) for effective therapy

The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical r...

Hallmarks of Cancer: The Next Generation

The basics of epithelial-mesenchymal transition

The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understoo...

The Hallmarks of Cancer

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

Creation of human tumour cells with defined genetic elements

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

A number of genetic mutations have been identified in human breast cancers, yet the specific combinations of mutations required in concert to form breast carcinoma cells remain ...

Mesenchyme Forkhead 1 ( <i>FOXC2</i> ) plays a key role in metastasis and is associated with aggressive basal-like breast cancers

The metastatic spread of epithelial cancer cells from the primary tumor to distant organs mimics the cell migrations that occur during embryogenesis. Using gene expression profi...

The Spemann organizer gene, <i>Goosecoid</i> , promotes tumor metastasis

The process of invasion and metastasis during tumor progression is often reminiscent of cell migration events occurring during embryonic development. We hypothesized that genes ...

Metastasis genes: A progression puzzle