Abstract
Significance Our analyses uncover general immunogenic activity of bacterial T3SS needle protein and identify human NAIP and mouse NAIP1 as cytosolic innate immune sensors of bacterial T3SS needle protein. These results, together with our previous studies, establish a complete framework for understanding NLRC4-mediated detection of bacterial virulence products by the NAIP family inflammasome receptors. The inflammasome-stimulating activity of bacterial T3SS needle proteins and the difference between mouse and human NAIP inflammasome also may provide guidance in vaccine development.
Keywords
InflammasomeNLRC4Shigella flexneriFlagellinBiologySecretionType three secretion systemMicrobiologyCell biologyReceptorEscherichia coliCaspase 1BiochemistryMutant
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Publication Info
- Year
- 2013
- Type
- article
- Volume
- 110
- Issue
- 35
- Pages
- 14408-14413
- Citations
- 399
- Access
- Closed
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Cite This
Jieling Yang,
Yue Zhao,
Jianjin Shi
et al.
(2013).
Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation.
Proceedings of the National Academy of Sciences
, 110
(35)
, 14408-14413.
https://doi.org/10.1073/pnas.1306376110
Identifiers
- DOI
- 10.1073/pnas.1306376110