Yue Zhao

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Inflammatory caspases are innate immune receptors for intracellular LPS

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity

The <scp>NAIP</scp>–<scp>NLRC</scp>4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

Summary Bacterial flagella and type III secretion system (T3 SS ) are evolutionarily related molecular transport machineries. Flagella mediate bacterial motility; the T3 SS deli...

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

Significance Our analyses uncover general immunogenic activity of bacterial T3SS needle protein and identify human NAIP and mouse NAIP1 as cytosolic innate immune sensors of bac...