Increased Mortality Associated with Growth Hormone Treatment in Critically Ill Adults

Abstract

In patients with prolonged critical illness, high doses of growth hormone are associated with increased morbidity and mortality.

Keywords

MedicineIntensive care unitMechanical ventilationIntensive carePlaceboSepsisConfidence intervalRelative riskRandomized controlled trialMortality rateInternal medicineIntensive care medicine

Related Publications

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

Xiaobo Yang , Yu Yuan , Jiqian Xu +13 more

2020 The Lancet Respiratory Medicine 10565 citations

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Giacomo Grasselli , Alberto Zangrillo , Alberto Zanella +97 more

In this case series of critically ill patients with laboratory-confirmed COVID-19 admitted to ICUs in Lombardy, Italy, the majority were older men, a large proportion required m...

2020 JAMA 5742 citations

Intensive Insulin Therapy in Critically Ill Patients

Greet Van den Berghe , Pieter Wouters , Frank Weekers +7 more

Intensive insulin therapy to maintain blood glucose at or below 110 mg per deciliter reduces morbidity and mortality among critically ill patients in the surgical intensive care...

2001 New England Journal of Medicine 9922 citations

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

Jonathan A C Sterne , Srinivas Murthy , Janet Dı́az +35 more

In this prospective meta-analysis of clinical trials of critically ill patients with COVID-19, administration of systemic corticosteroids, compared with usual care or placebo, w...

2020 JAMA 2310 citations

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Gordon R. Bernard , Jean‐Louis Vincent , Pierre‐François Laterre +8 more

Treatment with drotrecogin alfa activated significantly reduces mortality in patients with severe sepsis and may be associated with an increased risk of bleeding.

2001 New England Journal of Medicine 6116 citations

Publication Info

Year: 1999
Type: article
Volume: 341
Issue: 11
Pages: 785-792
Citations: 992
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Increased Mortality Associated with Growth Hormone Treatment in Critically Ill Adults

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

992

OpenAlex

Cite This

APA Style

                            
                                
                                    Erika Wilkman, 
                                
                                    Michael Skovbo Windahl, 
                                
                                    G. Vundelinckx
                                
                                et al.
                            
                            (1999). 
                            Increased Mortality Associated with Growth Hormone Treatment in Critically Ill Adults. 
                            New England Journal of Medicine
                            , 341
                            (11)
                            , 785-792.
                            https://doi.org/10.1056/nejm199909093411102
                        

Identifiers

DOI: 10.1056/nejm199909093411102