iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL

Abstract

Abstract The previous edition of the consensus guidelines of the International Workshop on Chronic Lymphocytic Leukemia (iwCLL), published in 2008, has found broad acceptance by physicians and investigators caring for patients with CLL. Recent advances including the discovery of the genomic landscape of the disease, the development of genetic tests with prognostic relevance, and the detection of minimal residual disease (MRD), coupled with the increased availability of novel targeted agents with impressive efficacy, prompted an international panel to provide updated evidence- and expert opinion–based recommendations. These recommendations include a revised version of the iwCLL response criteria, an update on the use of MRD status for clinical evaluation, and recommendations regarding the assessment and prophylaxis of viral diseases during management of CLL.

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Affiliated Institutions

• Peter MacCallum Cancer Centre AU
• University of California, Irvine US
• Universität Ulm DE
• The University of Melbourne AU
• Feinstein Institute for Medical Research US
• St James's University Hospital GB
• Institute of Cancer Research GB
• Vita-Salute San Raffaele University IT
• University of California, San Diego US
• Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases DE
• Georgetown University US
• The Ohio State University US
• The Royal Melbourne Hospital AU
• Institut Pasteur de Montevideo UY
• The University of Texas MD Anderson Cancer Center US
• Universitat de Barcelona ES
• University of Cologne DE
• Medical University of Lodz PL

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