Massively parallel functional dissection of mammalian enhancers in vivo

Rupali P Patwardhan; Joseph B. Hiatt; Daniela Witten; Mee J. Kim; Robin P. Smith; Dalit May; Choli Lee; Jennifer M. Andrie; Su In Lee; Gregory M. Cooper; Nadav Ahituv; L Pennacchio; Jay Shendure

doi:10.1038/nbt.2136

Keywords

EnhancerBiologyGeneticsHaplotypeMutantComputational biologyRegulatory sequenceGeneTranscription factorAllele

Affiliated Institutions

Related Publications

Going the Distance: A Current View of Enhancer Action

Elizabeth M. Blackwood , James T. Kadonaga

In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA intermediates from which protein products are synthesized. Transcriptional enhancers are discrete...

1998 Science 824 citations

Interpreting non-coding variation in complex disease genetics

Lucas D. Ward , Manolis Kellis

Association studies provide genome-wide information about the genetic basis of complex disease, but medical research has primarily focused on protein-coding variants, due to the...

2012 DSpace@MIT (Massachusetts Institute o... 511 citations

The accessible chromatin landscape of the human genome

Robert E. Thurman , Eric Rynes , Richard Humbert +59 more

DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, in...

2012 Nature 2799 citations

High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells

Alan P. Boyle , Lingyun Song , Bum-Kyu Lee +6 more

Regulation of gene transcription in diverse cell types is determined largely by varied sets of cis -elements where transcription factors bind. Here we demonstrate that data from...

2010 Genome Research 326 citations

Genome-wide map of regulatory interactions in the human genome

Nastaran Heidari , Douglas H. Phanstiel , Chao He +5 more

Increasing evidence suggests that interactions between regulatory genomic elements play an important role in regulating gene expression. We generated a genome-wide interaction m...

2014 Genome Research 292 citations

Publication Info

Year: 2012
Type: article
Volume: 30
Issue: 3
Pages: 265-270
Citations: 564
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Massively parallel functional dissection of mammalian enhancers in vivo

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

564

OpenAlex

Cite This

APA Style

                            
                                
                                    Rupali P Patwardhan, 
                                
                                    Joseph B. Hiatt, 
                                
                                    Daniela Witten
                                
                                et al.
                            
                            (2012). 
                            Massively parallel functional dissection of mammalian enhancers in vivo. 
                            Nature Biotechnology
                            , 30
                            (3)
                            , 265-270.
                            https://doi.org/10.1038/nbt.2136
                        

Identifiers

DOI: 10.1038/nbt.2136