Abstract
Programmed cell death occurs in most animal tissues at some stage of their development, but the molecular mechanism by which it is executed is unknown. For some mammalian cells, programmed death seems to occur by default unless suppressed by signals from other cells. Such dependence on specific survival signals provides a simple way to eliminate misplaced cells, for regulating cell numbers and, perhaps, for selecting the fittest cells. But how general is this dependence on survival signals?
Keywords
Programmed cell deathSurvival of the fittestCell survivalCell biologyCellBiologyApoptosisCell fate determinationGeneticsGeneTranscription factor
MeSH Terms
AnimalsCaenorhabditisCell CommunicationCell DeathCell SurvivalMammalsOrgan SpecificitySignal Transduction
Affiliated Institutions
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Publication Info
- Year
- 1992
- Type
- review
- Volume
- 356
- Issue
- 6368
- Pages
- 397-400
- Citations
- 2640
- Access
- Closed
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Cite This
Martin Raff
(1992).
Social controls on cell survival and cell death.
Nature
, 356
(6368)
, 397-400.
https://doi.org/10.1038/356397a0
Identifiers
- DOI
- 10.1038/356397a0
- PMID
- 1557121