Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie , Pablo Tamayo , Jesse S. Boehm , David A. Barbie , Pablo Tamayo , Jesse S. Boehm , So Young Kim , Susan E. Moody , Ian F. Dunn , Anna C. Schinzel , Péter Sandy , Etienne Meylan , Claudia Scholl , Stefan Fröhling , Edmond M. Chan , Martin L. Sos , Kathrin Michel , Craig H. Mermel , Serena J. Silver , Barbara A. Weir , Jan H. Reiling , Qing Sheng , Piyush B. Gupta , Raymond Wadlow , Hanh Le , Sebastian Hoersch , Ben S. Wittner , Sridhar Ramaswamy , David M. Livingston , David M. Sabatini , Matthew Meyerson , Roman K. Thomas , Eric S. Lander , Jill P. Mesirov , David E. Root , D. Gary Gilliland , Tyler Jacks , William C. Hahn
2009 Nature 3,981 citations

Keywords

KRASCancer researchRNA interferenceBiologyCancerOncogenePumaMutantSynthetic lethalityRNAGeneMutationComputational biologyGeneticsCell cycle

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Year
2009
Type
article
Volume
462
Issue
7269
Pages
108-112
Citations
3981
Access
Closed

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David A. Barbie, Pablo Tamayo, Jesse S. Boehm et al. (2009). Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature , 462 (7269) , 108-112. https://doi.org/10.1038/nature08460

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DOI
10.1038/nature08460