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Visible light photoredox catalysis: applications in organic synthesis
The use of visible light sensitization as a means to initiate organic reactions is attractive due to the lack of visible light absorbance by organic compounds, reducing side rea...
An Efficient mRNA‐Dependent Translation System from Reticulocyte Lysates
A simple method is described for converting a standard rabbit reticulocyte cell‐free extract (lysate) into an mRNA‐dependent protein synthesis system. The lysate is preincubated...
The Evolution of Social Behavior
▪ Abstract The literature on effects of habitat fragmentation on biodiversity is huge. It is also very diverse, with different authors measuring fragmentation in different ways ...
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Autophagy is an intracellular bulk degradation process through which a portion of the cytoplasm is delivered to lysosomes to be degraded. Although the primary role of autophagy ...
Real-Time DNA Sequencing from Single Polymerase Molecules
We present single-molecule, real-time sequencing data obtained from a DNA polymerase performing uninterrupted template-directed synthesis using four distinguishable fluorescentl...
Oncogenic kinase signalling
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and multicellular communication in metazoans. Their ...
Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
Recent functional imaging studies have revealed coactivation in a distributed network of cortical regions that characterizes the resting state, or default mode, of the human bra...
Effect size, confidence interval and statistical significance: a practical guide for biologists
Abstract Null hypothesis significance testing (NHST) is the dominant statistical approach in biology, although it has many, frequently unappreciated, problems. Most importantly,...