Publications
Explore 1,888 academic publications
Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.
1. Spinal cord and hippocampal neurones in cell culture were voltage clamped using the tight‐seal, whole‐cell recording technique. The concentration of sodium and a series of di...
Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia
Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Esch...
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. ...
Mechanism of Action of<i>Melaleuca alternifolia</i>(Tea Tree) Oil on<i>Staphylococcus aureus</i>Determined by Time-Kill, Lysis, Leakage, and Salt Tolerance Assays and Electron Microscopy
ABSTRACT The essential oil of Melaleuca alternifolia (tea tree) has broad-spectrum antimicrobial activity. The mechanisms of action of tea tree oil and three of its components, ...
Learning from Mistakes is Easier Said Than Done: Group and Organizational Influences on the Detection and Correction of Human Error
This research explores how group- and organizational-level factors affect errors in administering drugs to hospitalized patients. Findings from patient care groups in two hospit...
Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease
Abdominal liposuction does not significantly improve obesity-associated metabolic abnormalities. Decreasing adipose tissue mass alone will not achieve the metabolic benefits of ...
Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells
Abstract Lapatinib (GW572016) is a selective inhibitor of both epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. Here, we explore the therapeutic potential of ...
Iron Oxide Nanoparticles for Sustained Delivery of Anticancer Agents
We have developed a novel water-dispersible oleic acid (OA)-Pluronic-coated iron oxide magnetic nanoparticle formulation that can be loaded easily with high doses of water-insol...
Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries. Principal results from EUROASPIRE II Euro Heart Survey Programme
This European survey of coronary patients shows a high prevalence of unhealthy lifestyles, modifiable risk factors and inadequate use of drug therapies to achieve blood pressure...