Tarjei S. Mikkelsen

The NIH Roadmap Epigenomics Mapping Consortium

Positive Natural Selection in the Human Lineage

Positive natural selection is the force that drives the increase in prevalence of advantageous traits, and it has played a central role in our development as a species. Until re...

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Massively parallel digital transcriptional profiling of single cells

An integrated encyclopedia of DNA elements in the human genome

The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) pro...

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Defining the transcriptional dynamics of a temporal process such as cell differentiation is challenging owing to the high variability in gene expression between individual cells...