Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

Abstract

In this retrospective analysis of data sets from patients with sepsis, 4 clinical phenotypes were identified that correlated with host-response patterns and clinical outcomes, and simulations suggested these phenotypes may help in understanding heterogeneity of treatment effects. Further research is needed to determine the utility of these phenotypes in clinical care and for informing trial design and interpretation.

Keywords

MedicineSepsisCohortRandomized controlled trialInternal medicineRetrospective cohort studyClinical trialCohort studyIntensive careIntensive care medicine

Affiliated Institutions

Related Publications

Predictors of hospital mortality in a population-based cohort of patients with acute lung injury*

Colin R. Cooke , Jeremy M. Kahn , Ellen Caldwell +4 more

The predictors of mortality in patients with acute lung injury are similar to those predictive of mortality in the general intensive care unit population, indicating disease het...

2008 Critical Care Medicine 109 citations

APACHE—acute physiology and chronic health evaluation: a physiologically based classification system

William A. Knaus , Jack E. Zimmerman , Douglas P. Wagner +2 more

Investigations describing the utilization pattern and documenting the value of intensive care are limited by the lack of a reliable and valid classification system. In this pape...

1981 Critical Care Medicine 2170 citations

Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis

R. D. Piper , Deborah J. Cook , Roger C. Bone +1 more

The success of clinical trials of sepsis therapies is predicated on the generation and interpretation of sound preclinical data. In this review, we have attempted to outline an ...

1996 Critical Care Medicine 133 citations

A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit

Simon Finfer , Rinaldo Bellomo , Neil Boyce +3 more

In patients in the ICU, use of either 4 percent albumin or normal saline for fluid resuscitation results in similar outcomes at 28 days.

2004 New England Journal of Medicine 2813 citations

Cerebrospinal fluid studies in an intensive care nursery

Marilyn Escobedo , Leslie L. Barton , Joseph J. Volpe

Prospective and retrospective data were collected from 394 cerebrospinal fluid (CSF) examinations performed in premature and full term infants in a neonatal intensive care unit ...

1975 Journal of Perinatal Medicine 17 citations

Publication Info

Year: 2019
Type: article
Volume: 321
Issue: 20
Pages: 2003-2003
Citations: 1290
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1290

OpenAlex

Cite This

APA Style

                            
                                
                                    Christopher Seymour, 
                                
                                    Jason Kennedy, 
                                
                                    Shu Wang
                                
                                et al.
                            
                            (2019). 
                            Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. 
                            JAMA
                            , 321
                            (20)
                            , 2003-2003.
                            https://doi.org/10.1001/jama.2019.5791
                        

Identifiers

DOI: 10.1001/jama.2019.5791