Detection and localization of surgically resectable cancers with a multi-analyte blood test

Abstract

SEEK and you may find cancer earlier Many cancers can be cured by surgery and/or systemic therapies when detected before they have metastasized. This clinical reality, coupled with the growing appreciation that cancer's rapid genetic evolution limits its response to drugs, have fueled interest in methodologies for earlier detection of the disease. Cohen et al. developed a noninvasive blood test, called CancerSEEK that can detect eight common human cancer types (see the Perspective by Kalinich and Haber). The test assesses eight circulating protein biomarkers and tumor-specific mutations in circulating DNA. In a study of 1000 patients previously diagnosed with cancer and 850 healthy control individuals, CancerSEEK detected cancer with a sensitivity of 69 to 98% (depending on cancer type) and 99% specificity. Science , this issue p. 926 ; see also p. 866

Keywords

Affiliated Institutions

• Peter MacCallum Cancer Centre AU
• Mayo Clinic US
• University of Pittsburgh US
• The University of Melbourne AU
• Western Health AU
• Johns Hopkins Medicine US
• San Raffaele University of Rome IT
• Sidney Kimmel Comprehensive Cancer Center US
• Sidney Kimmel Cancer Center US
• The University of Texas MD Anderson Cancer Center US
• Johns Hopkins University US
• Howard Hughes Medical Institute US
• Memorial Sloan Kettering Cancer Center US
• Mayo Clinic in Arizona US
• Cancer Genetics (United States) US
• Cancer Research Center US
• Walter and Eliza Hall Institute of Medical Research AU

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