Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients’ advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities of treatment, including targeted therapies, provide hope for improving patient outcomes. Sections of the manuscript have been updated to be concordant with the most recent update to the guidelines. This manuscript focuses on the available systemic therapy approaches, specifically the treatment options for locally advanced and metastatic disease.

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Affiliated Institutions

• UCSF Helen Diller Family Comprehensive Cancer Center US
• Breast Cancer Research Foundation US
• University of Tennessee Health Science Center US
• University of Utah US
• Huntsman Cancer Institute US
• City Of Hope National Medical Center US
• Duke Cancer Institute
• O'Neal Comprehensive Cancer Center
• Sidney Kimmel Comprehensive Cancer Center US
• Dana-Farber Brigham Cancer Center US
• Stanford Cancer Institute
• The University of Texas MD Anderson Cancer Center US
• Barnes-Jewish Hospital US
• University of Pennsylvania US
• Susan Thompson Buffett Foundation US
• Seattle Cancer Care Alliance US
• Harold C. Simmons Comprehensive Cancer Center
• Cancer Research Center US
• Fred and Pamela Buffett Cancer Center
• Vanderbilt-Ingram Cancer Center
• Cleveland Clinic US
• Smilow Cancer Hospital US
• Massachusetts General Hospital US
• The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute US
• University of Colorado Cancer Center US
• Fred Hutch Cancer Center US
• Pancreatic Cancer Action Network US
• University of California, San Diego US
• Moffitt Cancer Center US
• University of Michigan US
• Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa ZA
• University of Colorado Denver US
• UCLA Jonsson Comprehensive Cancer Center
• University Hospitals Seidman Cancer Center US
• Fox Chase Cancer Center US
• The University of Texas Southwestern Medical Center US
• Robert H. Lurie Comprehensive Cancer Center of Northwestern University
• University of Wisconsin Carbone Cancer Center US
• Cancer Institute (WIA) IN
• Jewish Hospital US
• Memorial Sloan Kettering Cancer Center US
• National Comprehensive Cancer Network

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