Abstract

Approximately half of the neurons produced during embryogenesis normally die before adulthood. Although target-derived neurotrophic factors are known to be major determinants of programmed cell death—apoptosis—the molecular mechanisms by which trophic factors interfere with cell death regulation are largely unknown. Overexpression of the bcl-2 proto-oncogene in cultured sympathetic neurons has now been shown to prevent apoptosis normally induced by deprivation of nerve growth factor. This finding, together with the previous demonstration of bcl-2 expression in the nervous system, suggests that the Bcl-2 protein may be a major mediator of the effects of neurotrophic factors on neuronal survival.

Keywords

Programmed cell deathNeurotrophinNeurotrophic factorsApoptosisBiologyMediatorCell biologyNerve growth factorOncogeneNeuroscienceCellNervous systemCell cycleGeneticsReceptor

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Year
1992
Type
article
Volume
258
Issue
5080
Pages
302-304
Citations
716
Access
Closed

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Irène Garcia, Isabelle Martinou, Yoshihide Tsujimoto et al. (1992). Prevention of Programmed Cell Death of Sympathetic Neurons by the <i>bcl-2</i> Proto-Oncogene. Science , 258 (5080) , 302-304. https://doi.org/10.1126/science.1411528

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DOI
10.1126/science.1411528