Abstract

Two dozen cellular proto-oncogenes have been discovered to date through the study of retroviruses and the use of gene transfer. They form a structurally and functionally heterogeneous group. At least five distinct mechanisms are responsible for their conversion to active oncogenes. Recent work provides experimental strategies by which many of these oncogenes, as well as oncogenes of DNA tumor viruses, may be placed into functional categories. These procedures may lead to definition of a small number of common pathways through which the various oncogenes act to transform cells.

Keywords

CarcinogenesisBiologyGeneDNAProto-OncogenesComputational biologyGeneticsCancer researchCell biologyOncogeneCell cycle

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Publication Info

Year
1983
Type
review
Volume
222
Issue
4625
Pages
771-778
Citations
1135
Access
Closed

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Hartmut Land, Luis F. Parada, Robert A. Weinberg (1983). Cellular Oncogenes and Multistep Carcinogenesis. Science , 222 (4625) , 771-778. https://doi.org/10.1126/science.6356358

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DOI
10.1126/science.6356358