Keywords
BiologyZinc fingerGeneticsGeneCold-shock domainHeterochronyRNA-binding proteinRNACell biologyUntranslated regionPhenotypeCaenorhabditis elegansTranscription factorOntogeny
Affiliated Institutions
Related Publications
Heterochronic Mutants of the Nematode <i>Caenorhabditis elegans</i>
Mutations in the Caenorhabditis elegans genes lin-14 , lin-28 , and lin-29 cause heterochronic developmental defects: the timing of specific developmental events in several tiss...
Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
The heterchronic gene lin-14 controls the temporal sequence of developmental events in the Caenorhabditis elegans postembryonic cell lineage. It encodes a nuclear protein that n...
Control of Developmental Timing by MicroRNAs and Their Targets
▪ Abstract In Caenorhabditis elegans the timing of many developmental events is regulated by heterochronic genes. Such genes orchestrate the timing of cell divisions and fates a...
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, ...
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
BACKGROUND: The microRNAs (miRNAs) are an extensive class of small noncoding RNAs (18 to 25 nucleotides) with probable roles in the regulation of gene expression. In Caenorhabdi...
Publication Info
- Year
- 1997
- Type
- article
- Volume
- 88
- Issue
- 5
- Pages
- 637-646
- Citations
- 841
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
841
OpenAlex
Cite This
Eric G. Moss,
Rosalind C. Lee,
Victor Ambros
(1997).
The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA.
Cell
, 88
(5)
, 637-646.
https://doi.org/10.1016/s0092-8674(00)81906-6
Identifiers
- DOI
- 10.1016/s0092-8674(00)81906-6